How to Use a Logitech MX Vertical Mouse

On this page (8 sections)

1. How do you connect a Logitech MX Vertical mouse?
2. How should you hold the MX Vertical?
3. What do the MX Vertical buttons do?
4. How do you adjust to the vertical shape?
5. Which mouse should you use with this setup?
6. How do you use the MX Vertical every day?
7. What should you do if the mouse does not respond?
8. How do you choose the right MX Vertical setup?

To use a Logitech MX Vertical mouse, connect it by Bluetooth or USB receiver, hold it in a relaxed handshake position, and move it with your arm. Use the cursor speed switch when you need a faster or slower pointer response.

The MX Vertical has a 57° vertical angle, a thumb rest, and an optical sensor with up to 4000 DPI. These features change how the mouse feels in daily work, so give your hand time to adjust rather than gripping it like a flat mouse.

This style suits desk users who spend long stretches clicking, scrolling, and moving across documents or multiple screens. It also suits people who work on a laptop and want a mouse that can switch between computer and tablet use.

Compared with a low, flat mouse, the upright body asks for a different kind of movement. Your hand wraps around the shell instead of lying flat on top, so small clicks and scrolls often come from your fingers and forearm.

Set it up close to your keyboard so your shoulder does not reach out to the side. Keep the desk surface clean and flat, turn the mouse on, and check that the connection is active before you start work.

A slower pointer speed often helps with menus, small icons, and careful dragging. A faster setting can suit browsing, spreadsheets, and wide displays where the hand needs to travel less far.

Do not squeeze the sides tightly, and do not bend your wrist to steer the pointer. Light contact and steady forearm movement make the vertical shape easier to learn and more comfortable over a full workday.

Care is simple, but it still matters. Wipe the textured surface and sensor area with a dry or lightly damp cloth, keep liquids away from the mouse and receiver, and store it where the buttons and wheel will not be pressed by accident.

To compare upright and other ergonomic shapes, read vertical mouse vs ergonomic mouse.

How do you connect a Logitech MX Vertical mouse?

Choose Bluetooth when you want to pair directly with a compatible device, or use the USB receiver for a simple wireless connection. The MX Vertical supports Bluetooth and USB receiver connectivity.

For Bluetooth pairing, turn on the mouse and open your computer's Bluetooth settings. Select the MX Vertical when it appears, then complete the pairing steps shown by your operating system.

For receiver setup, insert the USB receiver into an available USB port and turn on the mouse. Keep the receiver close to the mouse when possible, especially if your desk has other wireless devices nearby.

The Logitech Mouse MX Vertical, 910-005448, connects through Bluetooth or USB receiver and works with Windows and macOS. Its listed wireless range is 5 meters, and its included lithium polymer battery is rated for an average battery life of 4 months.

If you are comparing this style with another shape, our guide to ergonomic keyboard and mouse setups explains how a mouse and keyboard can work together at a desk.

How should you hold the MX Vertical?

Place your hand around the mouse as if you are making a relaxed handshake. For wrist-rest placement, see how to use a mouse wrist rest.

Keep your thumb on the thumb rest, let your fingers rest over the buttons, and avoid squeezing the sides.

The 57° angle turns your hand away from the palm-down position used by a standard mouse. That change may feel unusual at first, so use light pressure and make small movements while you learn the shape.

Keep your wrist as straight as your desk allows. Move the mouse with your forearm when you need to travel across the screen instead of repeatedly bending your wrist.

The Logitech MX Vertical Wireless Mouse Ergonomic Design - Graphite has a textured rubber surface, a right-hand layout, and a 57° vertical angle. Its product information describes a natural handshake position and a thumb rest.

The advanced graphite model includes the mouse, quickstart guide, receiver, and USB-C cable. It is identified as compatible with Windows, macOS, and iPadOS.

What do the MX Vertical buttons do?

Use the main buttons for regular clicks, the scroll wheel for page movement, and the cursor speed switch when pointer response needs to change. The MX Vertical models in this guide have 4 buttons.

The cursor speed switch is useful when you move between tasks. A slower setting can make small selections easier, while a faster setting can reduce the distance your hand travels across a wide display.

Use the scroll wheel for documents and web pages. Place your fingers lightly over the main buttons so you can click without pressing down on the shell.

If you need a different vertical shape, compare the best ergonomic vertical mouse options before choosing a replacement. Hand size, button reach, and connection type all matter more than the word “ergonomic” by itself.

How do you adjust to the vertical shape?

Start with short work periods and keep your grip relaxed. The goal is to let the mouse's shape guide your hand position without forcing your wrist into a new angle.

Place the mouse near the keyboard so your arm does not reach far to the side. Keep your shoulder relaxed and avoid lifting your wrist while moving the pointer.

Use a larger pointer speed if the mouse feels slow across your screen. If the pointer jumps too far during precise work, lower the speed and make smaller movements.

A different grip may suit a different hand size. Our Logitech MX Vertical mouse review looks at the model's design and controls in more detail.

Which mouse should you use with this setup?

The Logitech models suit readers who want a vertical layout with Bluetooth or receiver connectivity. The advanced graphite version adds a 57° angle, textured rubber surface, cursor speed switch, and compatibility with Windows, macOS, and iPadOS.

The Anker 2.4G Wireless Ergonomic Mouse uses a USB receiver rather than Bluetooth. It has a right-hand vertical design, 5 buttons, 800, 1200, and 1600 DPI settings, next and previous buttons, and a power-saving mode after 8 minutes of inactivity.

The Anker mouse uses 2 AAA batteries, which are not included. Its USB receiver is stored in the bottom of the mouse, and the mouse measures 120 x 62.8 x 74.8 mm.

Choose the Anker if USB receiver use and extra browsing buttons fit your desk. Choose the Logitech MX Vertical if Bluetooth, a 57° angle, or up to 4000 DPI tracking matters more.

For another Logitech comparison, see Logitech MX Vertical vs Lift to compare the two vertical mouse designs. If your keyboard is also part of the change, our Logitech Wave Keys MK670 review covers a compatible ergonomic keyboard option.

How do you use the MX Vertical every day?

Keep the mouse close, use light clicks, and change pointer speed when the task changes. These habits help you get the benefit of the vertical layout without treating the mouse as a medical device.

For browsing, use the scroll wheel and the model's available buttons. For precise work, slow the pointer if needed and guide the mouse with controlled forearm movement.

Charge or replace batteries according to the model you own. The advanced MX Vertical uses a USB-C cable in the listed package and has an average battery life of 4 months, while the Anker model requires 2 AAA batteries.

Keep the sensor area and desk surface free of dust. Wipe the outer surface with a dry or lightly damp cloth, and keep liquid away from the mouse and receiver.

If you are pairing a mouse with the ERGO K860, see the guide to the best Logitech ERGO K860 mouse pairings. It can help you choose between a vertical mouse with Bluetooth, a receiver, or both.

What should you do if the mouse does not respond?

Check power, the connection method, and the receiver position first. Turn the mouse off and on, confirm the battery or charge status, and reconnect Bluetooth or the USB receiver.

If you use the Anker mouse, check that its receiver is inserted and that the batteries are installed. USB 3.0 devices may interfere with wireless devices, so moving the receiver to a host port or USB 2.0 connection may help.

If the pointer moves but feels too fast or slow, use the cursor speed switch on the MX Vertical. Also check the operating system's pointer settings before changing your hand position.

For a different Logitech shape, read how to use a Logitech Lift mouse. The same basics apply: pair the mouse, keep your hand relaxed, and place it close enough that your shoulder stays comfortable.

How do you choose the right MX Vertical setup?

Pick Bluetooth if you want direct wireless pairing, and pick the USB receiver if you prefer a receiver-based connection. Then set the pointer speed, keep the mouse near the keyboard, and give your hand time to learn the vertical grip.

Choose the Logitech Mouse MX Vertical for Bluetooth and USB receiver support across Windows and macOS. Choose the advanced graphite version if its 57° angle, textured rubber surface, cursor speed switch, and broader device compatibility fit your needs.

Choose the Anker 2.4G Wireless Ergonomic Mouse if you want 5 buttons, next and previous controls, adjustable 800 to 1600 DPI tracking, and USB receiver operation. For broader buying advice, return to the best ergonomic vertical mouse guide.

Frequently asked questions

How do you connect a Logitech MX Vertical mouse?

Connect the Logitech MX Vertical mouse through Bluetooth or its USB receiver. Turn on the mouse, open your computer's Bluetooth settings if you are pairing wirelessly, or insert the receiver and select the mouse when prompted.

The exact menu names depend on your operating system.

How do you change the speed on an MX Vertical mouse?

Press the cursor speed switch to change tracking speed on the MX Vertical. Its sensor reaches up to 4000 DPI, so the switch gives you a quick way to choose a faster or slower pointer response while you work.

How should you hold a Logitech MX Vertical mouse?

Rest your hand around the mouse in a relaxed handshake position, with your thumb on the thumb rest and your fingers over the buttons. Keep your wrist straight and move the mouse from your arm instead of gripping tightly or bending your wrist.

Does the Logitech MX Vertical work with Mac and Windows?

Yes. The Logitech MX Vertical works with Windows and macOS.

The product information also identifies the advanced model as compatible with iPadOS, while Bluetooth and USB receiver setup steps can vary by device.